GLOBAL TRANSDERMAL DRUG DELIVERY MARKET to 2020

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Published February 2015

GLOBAL TRANSDERMAL DRUG DELIVERY MARKET to 2020 Strategic Analysis, Technologies, Competitor Profiles, Financial Evaluation, Product Pipeline Assessment and SWOT Investigation

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Description

Published February 2015

Download sample pages here

The GLOBAL TRANSDERMAL DRUG DELIVERY MARKET to 2020 report is a comprehensive account of the market size, segmentation, key players, SWOT analysis, influential technologies, and business and economic environments. The report is supported by 320 tables & figures over 280 pages. This report is presented as follows:

  • By Company (e.g., JANSSEN, MYLAN, ACTAVIS, GLAXOSMITHKLINE, BAYER, NOVARTIS, NOVEN, LAVIPHARM, PROSTRACKEN, NITTO DENTO)
  • By Geography (Global, USA)
  • By Parent Market (Drug Delivery Systems, Advanced Drug Delivery Systems)
  • By Sub-market (Generics, Women’s Health, Analgesics, Neuropathic Pain)

 

A wealth of financial data & business strategy information is provided including:

 

  • Up-to-date company financials, sales & revenue figures
  • Revenue and market forecasts
  • Business model strategies for drug delivery, pharmaceutical and biotechnology companies
  • Comprehensive account of company products, financials & portfolios

SWOT, Economic & Regulatory Environment specifics include:

 

  • Key strengths, weaknesses and threats influencing leading player position within the market
  • Technologies driving the market (e.g., chemical enhancers, microneedles)
  • Top fastest growing market segments and emerging opportunities
  • Top pharmaceutical companies within the market
  • Comprehensive product portfolios, R&D activity and pipeline products
  • M&A activity and future strategies of top companies
  • High demand and unmet need enhances the market
  • Challenges of the transdermal drug delivery market

 

This report highlights a number of significant companies and gives details of their operations, products, financials and business strategy.

  • Actavis
  • Actelion
  • GlaxoSmithKline
  • Bayer
  • Mylan Pharmaceuticals
  • Novartis
  • Upsher-Smith
  • Ascend Therapeutics
  • AMAG Pharmaceuticals (Lumara Health, KV Pharm/Ther-Rx Corp)
  • Janssen Pharmaceuticals
  • Noven Pharmaceuticals
  • ProStrakan
  • Shire
  • Hercon Pharmaceutical
  • Kremers Urban Pharmaceuticals
  • Nitto Denko
  • Teva Pharmaceutical Industries
  • Endo International
  • Teikoku USA
  • Boehringer Ingelheim
  • 3M
  • UCB
  • ParPharm

 

Table of Contents

1.0          Executive Summary                                                                                                                          17

1.1          Objectives of Report                                                                                                                           17

1.2          Data Sources & Methodology                                                                                                          18

1.3          Key Findings & Observations                                                                                                           19

1.3.1       The Global Drug Delivery Market has a Growth Rate of 5%                                                     19

1.3.2       The Transdermal Drug Delivery Market is Growing Vertically                                                 20

1.3.3       Who are the Leading Players in the Market?                                                                                 20

1.3.4       Neurodegenerative Disorders Such as Alzheimer’s and Parkinson’s Disease Will Propel the Future Market                                                                                                                                                                  21

1.3.5       Why is the Transdermal Drug Delivery Market so Promising?                                                  21

1.3.6       What are the Main Drivers of the Market?                                                                                    21

1.3.7       First, Second and Third Generation Drug Delivery Systems                                                      22

1.3.8       The Niche Market of Commercially Available Skin Models                                                      22

1.3.9       Transdermal Drug Delivery Technologies are Providing the Market with Niche Spaces     22

1.3.10     Nanotechnology is Transforming Transdermal Drug Delivery                                                   23

1.3.11     Can Transdermal Drug Delivery be Applied to Cancer Vaccination?                                      23

1.3.12     Gene Therapy Advancement Using Transdermal Delivery                                                         23

 

2.0          Transdermal Drug Delivery                                                                                                           24

2.1          Introduction                                                                                                                                         24

2.2          Developments of Transdermal Drug Delivery to Date                                                                 24

2.3          The Skin – Anatomy and Physiology                                                                                              27

2.3.1       Drug Administration via the Intracellular Pathway                                                                      28

2.3.2       Drug Administration via the Intercellular Pathway                                                                      29

2.3.3       Fick’s Law                                                                                                                                            29

2.4          Factors that Influence Transdermal Drug Delivery                                                                      29

2.4.1       Parameters Influencing Skin Permeability                                                                                      29

2.4.1.1    The Vehicle                                                                                                                                           29

2.4.1.2    Drug Concentration                                                                                                                            30

2.4.1.3    Partition Coefficient                                                                                                                           30

2.4.1.4    Variations in Skin Type                                                                                                                     30

2.5          Strategies to Enhance Transdermal Drug Delivery                                                                       30

2.5.1       1st Generation Delivery Systems                                                                                                      30

2.5.2       2nd Generation Delivery Systems                                                                                                     31

2.5.2.1                    Chemical Enhancers                                                                                                           31

2.5.2.2                    Physical Enhancers                                                                                                             32

2.5.3       3rd Generation Delivery Systems                                                                                                   32

2.6          Comparison of Transdermal Delivery with Other Methods                                                        34

2.7          Advantages of Transdermal Drug Delivery                                                                                    35

2.7.1       First-Pass Metabolism                                                                                                                        35

2.8          Disadvantages of Transdermal Delivery                                                                                         36

2.9          Complications of Transdermal Therapy                                                                                         36

2.9.1       Overdose                                                                                                                                               37

2.9.2       Skin Sensitivity and Reactions                                                                                                         37

  • MRI-Induced Skin Burns 38

 

3.0          Biomechanical & Pharmacological Elements Effecting Transdermal Drug Delivery   39

3.1          Factors That Influence Transdermal Drug Delivery                                                                      39

3.1.1       Rate of Permeation Across the Skin                                                                                                39

3.1.2       Skin Characteristics                                                                                                                            39

3.1.3       Drug Characteristics                                                                                                                           39

3.1.4       pH and Pharmacokinetics                                                                                                                  39

3.2          Transdermal Drug Design                                                                                                                  40

3.2.1       Factors That Affect the Absorption of the Drug                                                                            40

3.2.1.1    Hydration and Temperature                                                                                                              40

3.2.1.2    Biotransformation of the Drug in the Skin                                                                                     40

3.2.2       Selecting Drug and Vehicle                                                                                                               40

3.2.3       Drug Modification                                                                                                                              40

3.2.3.1    Ion-Pair Formation                                                                                                                             40

3.2.3.2 Pro-Drug                                                                                                          40

3.2.3.3    Drug Complexation                                                                                                                            41

3.2.4       Thermodynamic Activity of the Drug within the Vehicle                                                            41

3.2.4.1    Eutectic Systems                                                                                                                                 41

3.2.4.2    Vehicle Formulation                                                                                                                           41

3.2.4.3    Modification of the Stratum Corneum                                                                                            41

3.3          In Vitro Testing of Transdermal Drug Delivery Systems                                                            41

3.3.1       Static Franz Diffusion Cell                                                                                                                42

3.3.2       Side-Bi-Side Cells                                                                                                                               42

3.4          Commercially Available Skin Models for Transdermal Drug Testing                                      43

3.5          In vivo Testing of Transdermal Drug Delivery Systems                                                             43

3.5.1       In vivo Testing of Drug Delivery Systems                                                                                     44

3.5.2       Modelling of Transport Through the Skin                                                                                      44

 

4.0          Transdermal Drug Delivery Technologies                                                                                 46

4.1          Introduction                                                                                                                                         46

4.1.1       Local Application Formulations                                                                                                       46

4.1.2       Liquid Crystals for Transdermal Drug Delivery                                                                            46

4.1.3       Microemulsions for Transdermal Drug Delivery                                                                          47

4.1.4       Nanoemulsions for Transdermal Drug Delivery                                                                            49

4.1.5       Transdermal Gel Technology                                                                                                            50

4.1.6       Biphasix System                                                                                                                                  51

4.1.7       Penetration Enhancers                                                                                                                        51

4.1.8       Chemical Enhancers                                                                                                                           52

4.1.9       Nitric Oxide-Based Transdermal Drug Delivery                                                                          52

4.2          Vesicular Transdermal Carriers                                                                                                        52

4.2.1       Liposomes                                                                                                                                            53

4.2.2       Transfersomes                                                                                                                                     54

4.2.3       Ethosomes                                                                                                                                            55

4.2.4       Elastic Vesicles                                                                                                                                    55

4.3          Transdermal Patch                                                                                                                              56

4.3.1       Types of Transdermal Patch                                                                                                             57

4.3.1a     Single-layer Drug-in-Adhesive                                                                                                          57

4.3.1b     Multi-layer Drug-in-Adhesive                                                                                                           58

4.3.1c     Reservoir                                                                                                                                               58

4.3.1d     Matrix Patch                                                                                                                                        58

4.3.1e     Vapour Patch                                                                                                                                       59

4.3.2       Transdermal Patches Adhesives                                                                                                       59

4.3.3       h-Patch™ Controlled Release Micropump System                                                                      60

4.4          Patchless Transdermal Delivery System                                                                                         60

4.5          Metered-Dose Transdermal System                                                                                              60

4.6          Polymers for Transdermal Drug Delivery                                                                                       61

4.6.1       Film Forming Polymeric Solutions                                                                                                  61

4.7          Physical Methods to Promote Transdermal Delivery                                                                    62

4.7.1       Electrotransport                                                                                                                                   62

4.7.2       Electroporation                                                                                                                                    62

4.7.2.1    Drug delivery by Electroporation                                                                                                    63

4.7.2.2    Electrochemotherapy                                                                                                                         63

4.7.3       Cryoelectrophoresis                                                                                                                            64

4.7.4       Iontophoresis                                                                                                                                      64

4.7.4.1    Application of Iontophoresis for Drug Delivery                                                                            64

4.7.4.2    Companies with Technologies for Drug Delivery by Iontophoresis                                         65

4.8          How Combining Electrophoresis and Iontophoresis Impacts Drug Delivery                           66

4.9          Dermaportation                                                                                                                                   66

4.10        Radiofrequency-Driven Transdermal Delivery                                                                              67

4.11        Transcutaneous Drug Delivery by Electropulsation                                                                     67

4.11.1     Skin Patch Systems and Electrostatic Force                                                                                   67

4.12        Heat-Aided Drug Delivery                                                                                                                 67

4.13        Ultrasound                                                                                                                                            68

4.14        Magnetophoresis                                                                                                                                 69

4.15        Use of Lasers for Transdermal Drug Delivery                                                                               69

4.15.1     Laser-Induced Microporation                                                                                                           70

4.15.2     Painless Laser Injection                                                                                                                     70

4.15.3     Laser-Induced Pressure Waves                                                                                                         70

4.15.3.1                 Transdermal Drug Delivery by Laser-Assisted Changes in Skin                               71

4.16        How Pressurized Gas is Transforming Transdermal Drug Delivery                                          72

4.17        Microscission Induced by Gas                                                                                                         72

4.18        Role of Microelectromechanical Systems (MEMS) in Transdermal Drug Delivery               72

4.19        Microneedles and Dermal Microinjection                                                                                      74

4.20        Microneedle Arrays for Drug Delivery                                                                                            75

4.20.1     Microneedle Patch                                                                                                                              75

4.20.2     Applications of Microneedles                                                                                                           75

4.20.3     AdminPatch® Microneedle Array                                                                                                   75

4.20.4     Dissolving Microneedles                                                                                                                    76

4.21        Biodegradable Microneedles                                                                                                             76

4.22        Ceramic Microneedle Arrays                                                                                                            77

4.23        Dissolvable Microneedle Patches                                                                                                    77

4.23.1     MicorCor                                                                                                                                               78

4.23.2     MicroPyramid™                                                                                                                                  78

4.24        Microstructured Transdermal Systems                                                                                            78

4.25        Microneedle Transdermal Chip                                                                                                        79

4.26        Microneedle Applicator Device                                                                                                        80

4.27        DebioJect ™ Microneedle Technology                                                                                           80

4.28        Silk Microneedles                                                                                                                                81

4.29        Tattooing                                                                                                                                              82

4.30        ZP Patch Microprojections Technology                                                                                          82

4.31        Other Microneedle Products Currently Available                                                                         83

4.32        Needlefree injections                                                                                                                          83

4.33        Glide SDI® Solid Dose Injector                                                                                                      84

4.34        Jet Injection                                                                                                                                          84

4.34.1     Why is Needle-Free so Important?                                                                                                 85

4.34.2     Mini-Ject Needlefree Delivery System                                                                                           85

4.34.3     PharmaJet Stratis                                                                                                                                 86

4.34.4     MicroJet for Painless Injections                                                                                                       86

4.34.5     Nanoliter-Volume Pulsed Microjets                                                                                                86

4.35        SUMAVEL™ DosePro™ Needle-Less Injection                                                                         86

4.36        Skin Abrasion                                                                                                                                      87

 

5.0          How Nanotechnology is Transforming Transdermal Drug Delivery                                 88

5.1          Overview                                                                                                                                               88

5.2          Nanotechnology-Based Transdermal Drug Delivery                                                                    89

5.2.1       Nanobiotechnology for Transdermal Application                                                                         89

5.3          Nanoparticles and Nanoemulsions for Skin Disorders                                                                  90

5.4          Nanopatches                                                                                                                                        91

5.4.1       Vaxxas Nanopatch Technology                                                                                                       91

5.4.2       Effect of Mechanical Flexion on Penetration of Bucky Amino Acids Through the Skin      91

5.5          Inocyte™ Epidermal Drug Delivery System                                                                                 91

5.6          Ionic Nanoparticle Technology                                                                                                        92

5.7          Solid Lipid Nanoparticles (SLN) Gels                                                                                             93

5.8          siRNA- Nanoparticle Conjugates                                                                                                    93

5.9          Transdermal Nanoparticle Preparations for Systemic Effect                                                      94

5.10        Micellar Nanoparticle Estradiol Emulsion (MNPEE)                                                                   94

5.11        Transferosomes                                                                                                                                   95

5.12        Nanocarriers                                                                                                                                         95

5.13        Nanotechnology for Vaccination and Immunotherapy                                                                95

5.14        Safety Issues of Applications of Nanomaterial Carriers on the Skin                                         96

5.15        Comparison of Current Transdermal Drug Delivery Systems                                                    96

 

6.0          Transdermal Drug Delivery and Disease States                                                                       98

6.1          Antiaging Products                                                                                                                             98

6.2          Cancer                                                                                                                                                   98

6.2.1       δ-Amino Levulinic Acid                                                                                                                    98

6.2.2       Breast Cancer & Afimoxifene Gel                                                                                                   99

6.2.3       Cervical Cancer & Interferon α2b                                                                                                    99

6.2.4       Prostate Cancer & Nitroglycerine                                                                                                     99

6.2.5       Prostate Cancer & Estradiol Gel                                                                                                       100

6.2.6       Prostate Cancer & Leuprolide Acetate                                                                                            100

6.2.7       Skin Cancer & Caffeine                                                                                                                    100

6.2.8       Cancer Vaccines                                                                                                                                  101

6.2.8.1    Intradermal Delivery Using Adenoviral Vectors                                                                           101

6.2.8.2    Peptide Cancer Vaccines                                                                                                                   101

6.2.8.3    Electroporation of Anticancer Agents                                                                                             102

6.3          Cardiovascular Disease                                                                                                                      102

6.3.1       Transdermal Anticoagulants                                                                                                             102

6.3.2       Angina Pectoris                                                                                                                                    103

6.3.3       Atherosclerotic Cardiovascular Disease                                                                                         103

6.3.3.1    Transdermal Oestrogen for Prevention of Atherosclerotic Cardiovascular Disease              103

6.3.4       Congestive Heart Failure                                                                                                                    104

6.3.5       Hypertension                                                                                                                                        105

6.3.5.1    Clonidine                                                                                                                                               105

6.3.5.2    β-Blockers                                                                                                                                             105

6.3.5.3    Calcium Channel Blockers                                                                                                                106

6.4          Chronic Fatigue Syndrome                                                                                                               109

6.5          Contraception                                                                                                                                      109

6.5.1       Female Contraception                                                                                                                        109

6.5.1.1    Agile Therapeutics AG200-15                                                                                                          109

6.5.1.2    BAY86-5016 / FC Patch Low BAY86-5016                                                                                 110

6.5.1.3    Desogestrel                                                                                                                                            110

6.5.1.4    Ortho Evra™                                                                                                                                        111

6.5.2       Male Contraception                                                                                                                            111

6.5.2.1    Transdermal Progestin Plus Testosterone                                                                                       112

6.6          Diabetes                                                                                                                                                112

6.6.1       Insulin Drug Delivery                                                                                                                         112

6.6.1.1    V-Go                                                                                                                                                      112

6.6.1.2    GLP1 Agonist                                                                                                                                       113

6.7          Men’s Health                                                                                                                                       113

6.7.1       Benign Prostatic Hypertrophy                                                                                                          113

6.7.1.2    Tamsulosin Transdermal Drug Delivery System                                                                          114

6.7.2       Erectile Dysfunction                                                                                                                           114

6.7.2.1    Topical and Transdermal Preparation for Erectile Dysfunction                                                 115

6.7.3       Hypogonadism                                                                                                                                    115

6.7.3.1    Topical Testosterone                                                                                                                          116

6.8          Musculoskeletal Disease                                                                                                                    117

6.8.1       Osteoarthritis                                                                                                                                        117

6.8.2       Osteoporosis                                                                                                                                         117

6.8.2.1    Alendronate                                                                                                                                          118

6.8.2.2    Estrogen                                                                                                                                                118

6.8.2.3    Human Parathyroid Hormone                                                                                                          118

6.9          Nausea and Vomiting                                                                                                                         119

6.9.1       Chemotherapy-Induced                                                                                                                     119

6.9.2       Motion Sickness                                                                                                                                  119

6.9.3       Postoperative Vomiting                                                                                                                      119

6.10        Neurological Disease                                                                                                                          120

6.10.1     Alzheimer’s Disease                                                                                                                            120

6.10.1.1                 Arecoline                                                                                                                               120

6.10.1.2                 Rivastigmine                                                                                                                        120

6.10.1.3                 Donepezil                                                                                                                              120

6.11        Attention Deficit Hyperactivity Disorder                                                                                        121

6.11.1     Methylphenidate                                                                                                                                 121

6.12        Bipolar Disorder                                                                                                                                   121

6.12.1     Lithium                                                                                                                                                  121

6.13        Depression                                                                                                                                            122

6.13.1     Antidepressants                                                                                                                                   122

6.13.2     Selective Serotonin-Reuptake Inhibitors                                                                                        122

6.13.3     Fluoxetine                                                                                                                                             123

6.13.4     Monoamine Oxidase Inhibitors                                                                                                        123

6.13.5     Selegiline                                                                                                                                               123

6.13.6     Trazodone Hydrochloride                                                                                                                  124

6.13.7     Venlafaxine                                                                                                                                          124

6.13.8     Bupropion                                                                                                                                             124

6.14        Epilepsy                                                                                                                                                 124

6.15        Migraine                                                                                                                                                125

6.15.1     Sumatriptan                                                                                                                                         125

6.15.2     Zolmitriptan                                                                                                                                         126

6.16        Parkinson’s Disease                                                                                                                             126

6.16.1     Introduction                                                                                                                                         126

6.16.2     Dopamine Agonists                                                                                                                             126

6.16.2.1                 Levodopa                                                                                                                             127

6.16.2.2                 Rotigotine                                                                                                                             127

6.16.3                     Other Agents                                                                                                                        128

6.17        Restless Leg Syndrome                                                                                                                      128

6.17.1     Rotigotine                                                                                                                                             128

6.18        Schizophrenia                                                                                                                                      128

6.18.1     Haloperidol                                                                                                                                           129

6.18.2     Risperidone                                                                                                                                           129

6.18.3     Blonanserin                                                                                                                                          129

6.19        Tinnitus/Vertigo                                                                                                                                   130

6.20        Tourette syndrome                                                                                                                              131

6.20.1     Nicotine                                                                                                                                                 131

6.21        Multiple Sclerosis                                                                                                                                131

6.22        Respiratory Diseases                                                                                                                           131

6.22.1     Asthma and Chronic Obstructive Pulmonary Disease (COPD)                                                   131

6.23        Skin disorders                                                                                                                                       132

6.23.1     Cutaneous Leishmaniasis                                                                                                                  132

6.23.2     Hair Loss                                                                                                                                               132

6.23.3     Iontophoretic Drug Delivery for Nail Disorders                                                                            133

6.23.4     Psoriasis                                                                                                                                                 133

6.23.4.1                 Nanoemulsions for Paxitacel in Psoriasis                                                                        133

6.23.4.2                 Iontophoresis for Treatment of Psoriasis                                                                         134

6.24        Overactive Bladder and Urinary Incontinence                                                                              134

6.24.1     Oxybutynin                                                                                                                                          134

6.25        Pain                                                                                                                                                        134

6.25.1     Chronic Pain                                                                                                                                         134

6.25.2     Transdermal Local Anesthetics                                                                                                        135

6.25.3     Transdermal Fentanyl for the Management of Postoperative Pain                                            136

6.25.4     Fibromyalgia                                                                                                                                        136

6.25.5     Minor Medical Procedures                                                                                                                137

6.25.6     Neuralgia                                                                                                                                               137

6.25.6.1                 Lidoderm                                                                                                                              137

6.25.7     Nonsteroidal Anti-Inflammatory Drugs                                                                                          137

6.25.7.1                 Topical NSAIDs                                                                                                                  137

6.25.8     Ketoprofen                                                                                                                                           138

6.25.9     Opioids                                                                                                                                                  138

6.25.10                  Cancer Pain                                                                                                                          139

6.25.10.1               Fentanyl                                                                                                                                139

6.25.10.2               Nitroglycerine                                                                                                                      139

6.25.10.3               Buprenorphine                                                                                                                     140

6.26        Smoking Cessation                                                                                                                             140

6.26.1     Nicotine Replacement Therapy                                                                                                        140

6.26.2     Nicotine Patch in Pregnancy                                                                                                             140

6.27        Viral infections                                                                                                                                    142

6.27.1     Transdermal Nanoparticles for Immune Enhancement in HIV                                                  142

6.28        Women’s Health                                                                                                                                  143

6.28.1     Dysmenorrhea                                                                                                                                     143

6.28.2     Female Infertility                                                                                                                                 143

6.28.3     Female Sexual Arousal Disorder                                                                                                      144

6.28.4     Menopause                                                                                                                                           145

6.28.4.1                 Hormone Replacement Therapy                                                                                      145

6.28.4.2                 Estradiol                                                                                                                                145

6.28.4.3                 Parathyroid Hormone for Postmenopausal Osteoporosis                                             146

6.28.4.4                 Testosterone and Low Libido                                                                                            146

6.29        Transdermal Nutraceuticals                                                                                                               147

 

7.0          Gene Therapy and Transdermal Drug Delivery                                                                      148

7.1          Overview                                                                                                                                               148

7.2          Plasmid DNA and Electroporation                                                                                                  148

7.2.1       TriGrid™ Delivery System                                                                                                               149

7.2.2       CELLECTRA®                                                                                                                                   149

7.2.3       Magnetic Pulse Electroporation                                                                                                       150

7.3          Antisense Therapy                                                                                                                              150

 

8.0          Vaccines and Transdermal Drug Technology                                                                          152

8.1          Introduction                                                                                                                                         152

8.1.1       The Skin as an Immune Organ                                                                                                         152

8.1.1.1    Langerhans Cells- Epidermal Antigen Presenting Cells                                                               152

8.1.1.2    Keratinocytes- Immune Competent Epithelial cells                                                                      152

8.1.1.3    Dendritic Epidermal T Cells (DETC) γδ T cells -Specialised Resident Epithelial Cells        152

8.1.1.4    Epidermotropic T lymphocytes-Circulating T Cells that home to the Epidermis                    153

8.1.1.5    Melanocytes-Epidermal Pigment Cells With Immune Properties                                              153

8.2          Current Technologies                                                                                                                          153

8.2.1       Dissolvable Microneedle Array                                                                                                        153

8.2.2       Electroporation for Administering DNA Vaccines                                                                       154

8.2.3       Microneedles for Transdermal Vaccine Delivery                                                                         154

8.2.4       Needle-Free Delivery of Vaccines                                                                                                   155

8.3          Applications for Transdermal Vaccination                                                                                    156

8.3.1       HIV/AIDS Vaccine                                                                                                                             156

8.3.2       Transdermal DNA Influenza Vaccine                                                                                             157

8.3.3       Transdermal Aβ Vaccine for Alzheimer’s Disease                                                                       157

8.3.4       Transdermal Vaccine for Traveller’s Diarrhoea                                                                            157

 

9.0          Global Drug Delivery Market                                                                                                        158

9.1          Overview and Analysis                                                                                                                      158

9.2          USA Drug Delivery Market                                                                                                              160

9.3          European Drug Delivery Market                                                                                                      162

9.4          Emerging Drug Delivery Markets                                                                                                   164

9.5          The Advanced Drug Delivery Landscape                                                                                      164

9.6          Transdermal Drug Delivery Market                                                                                                166

9.7          Smoking Cessation Drug Market                                                                                                     169

9.7.1       Nicotine Replacement Therapeutics                                                                                                171

9.7.2       Non-Nicotine Containing Therapeutics                                                                                          171

9.7.3       Smoking Cessation Products in the Pipeline                                                                                   171

9.8          Neurodegenerative Disorders Such as Alzheimer’s & Parkinson’s disease will Propel the Future Market                                                                                                                                       172

9.9          How Transdermal Systems Relate to the Global Pain Market                                                   172

9.9.1       Neuropathic Pain Market (US, UK, France, Germany, Japan, Spain and Italy) 2014-2020 173

9.9.2       Transdermal Products Within the Neuropathic Pain Market                                                      176

9.10        How Transdermal Systems Relate Within the Generic Market                                                  176

9.11        Duragesic and Generic Fentanyl Transdermal System Competition                                         179

9.12        Lidocaine Market Analysis                                                                                                                181

9.13        Who are the Leading Players in the Market?                                                                                 182

9.14        What is Driving the Transdermal Drug Delivery Market?                                                          184

9.15        Increased Number of Geriatric and Pediatric Patients is Propelling the Market                     184

9.16        Unmet Needs Within the Transdermal Drug Delivery Market                                                   185

9.17        Women’s Health Market                                                                                                                    185

 

10.0        Transdermal Drug Delivery Company Business Profiles and Strategic Evaluation      187

10.1        Actavis                                                                                                                                                  187

10.2        Actelion                                                                                                                                                 188

10.3        GlaxoSmithKline                                                                                                                                 189

10.4        Bayer                                                                                                                                                     190

10.5        Mylan Pharmaceuticals                                                                                                                     191

10.6        Novartis                                                                                                                                                 191

10.7        Upsher-Smith                                                                                                                                       193

10.8        Ascend Therapeutics                                                                                                                          195

10.9        AMAG Pharmaceuticals (Lumara Health, KV Pharma/Ther-Rx Corp)                                   195

10.10      Janssen Pharmaceuticals                                                                                                                   195

10.11      Lavipharm                                                                                                                                            196

10.12      Noven Pharmaceuticals                                                                                                                     197

10.13      ProStrakan                                                                                                                                            198

10.14      Shire                                                                                                                                                       198

10.15      Hercon Pharmaceutical                                                                                                                      199

10.16      Kremers Urban Pharmaceuticals                                                                                                     199

10.17      Nitto Denko                                                                                                                                          199

10.18      Teva Pharmaceutical Industries                                                                                                       199

10.19      Endo International                                                                                                                              201

10.20      Teikoku USA                                                                                                                                        201

10.21      Boehringer Ingelheim                                                                                                                         201

10.22      3M                                                                                                                                                          203

10.23      UCB                                                                                                                                                       204

10.24      ParPharm                                                                                                                                          204

 

11.0        Transdermal Drug Delivery Company Financial Analysis                                                   208

11.1        Actavis                                                                                                                                                  210

11.2        Actelion                                                                                                                                                212

11.3        GlaxoSmithKline                                                                                                                                 217

11.3.1     ViiV Healthcare                                                                                                                                  218

11.4        Bayer                                                                                                                                                     218

11.5        Mylan Pharmaceuticals                                                                                                                     224

11.6        Novartis                                                                                                                                                 228

11.7        Janssen Pharmaceuticals (Johnson & Johnson)                                                                             232

11.8        Shire                                                                                                                                                       236

11.9        Nitto Dento                                                                                                                                           237

11.10      Teva Pharmaceuticals                                                                                                                        238

11.11      Endo International                                                                                                                              243

11.12      Boehringer Ingelheim                                                                                                                         246

11.13      3M                                                                                                                                                          248

11.14      UCB                                                                                                                                                       250

11.15      ParPharm                                                                                                                                              253

 

12.0        Current Transdermal Drug Delivery Products on the Market                                            255

12.1        Actavis                                                                                                                                                  255

12.1.1                     Androderm                                                                                                                           255

12.1.2                     Fentanyl Transdermal System                                                                                          255

12.1.3                     Lidocaine Topical Patch                                                                                                    255

12.1.4                     Oxytrol                                                                                                                                  255

12.2        Actelion                                                                                                                                                 256

12.2.1                     Vachlor Gel (mechlorethamine)                                                                                       256

12.3        GlaxoSmithKline                                                                                                                                 256

12.3.1                     Niquitin/Nicoderm                                                                                                               257

12.4        Bayer                                                                                                                                                     257

12.5        Mylan Pharmaceuticals                                                                                                                     258

12.5.1                     Clonidine Transdermal System                                                                                        258

12.5.2                     EMSAM (Selegiline Transdermal System)                                                                    258

12.5.3                     Estradiol Transdermal System                                                                                          258

12.5.4                     Fentanyl Transdermal System                                                                                          259

12.5.5                     Nitroglycerin Transdermal System                                                                                  259

12.5.6                     XULANE (Norelgestromin / Ethinyl Estradiol Transdermal System)                      259

12.6        Novartis                                                                                                                                                 259

12.6.1                     Exelon Patch (Rivastigmine Transdermal System)                                                       261

12.6.2                     Duragesic – Fentanyl Patches                                                                                            261

12.6.3                     Transderm Scop – Scopolamine Patches                                                                         262

12.7        Upsher-Smith                                                                                                                                       262

12.7.1                     Vogelxo – Testosterone (1%) Gel                                                                                    262

12.8        ASCEND Therapeutics                                                                                                                      262

12.8.1                     EstroGel®                                                                                                                             262

12.9        AMAG Pharmaceuticals (Lumara Health)                                                                                    262

12.9.1                     Evamist®                                                                                                                              262

12.10      Janssen Pharmaceuticals                                                                                                                   262

12.10.1                  OrthoEvra®                                                                                                                          263

12.10.2                  Duragesic®                                                                                                                          263

12.11      Lavipharm                                                                                                                                            263

12.11.1                  Fentadur                                                                                                                                264

12.11.2                  Nicotine Transdermal Patch                                                                                              264

12.11.3                  Acne Transdermal Patch                                                                                                    264

12.11.4                  Trinipatch                                                                                                                             264

12.12      Noven Pharmaceuticals                                                                                                                     264

12.12.1                  Minivelle®                                                                                                                           264

12.12.2                  CombiPatch®                                                                                                                      264

12.12.3                  Daytrana®                                                                                                                           265

12.13      ProStraken                                                                                                                                            265

12.13.1                  Sancuso®                                                                                                                             265

12.14      Shire                                                                                                                                                       265

12.14.1                  Daytrana® CII                                                                                                                    265

12.15      Hercon Pharmaceuticals                                                                                                                    265

12.15.1                  Nitroglycerin Transdermal System                                                                                  265

12.16      Kremers Urban Pharmaceuticals                                                                                                     265

12.16.1                  Nitroglycerin Transdermal System                                                                                  265

12.17      Nitto Dento                                                                                                                                           265

12.17.1                  Bisono Tape                                                                                                                         265

12.17.2                  Penles Tape                                                                                                                          265

12.17.3                  Passport Advanced Drug Delivery System                                                                    265

12.18      Teva Pharmaceuticals                                                                                                                        266

12.18.1                  Zecuity                                                                                                                                  266

12.18.2                  Transdermal Fentanyl (generic)                                                                                        266

12.18.3                  Tev Tropin                                                                                                                            266

12.19      Endo International                                                                                                                              267

12.19.1                  Lidoderm®Patch                                                                                                                 267

12.19.2                  Fortesa Gel                                                                                                                            267

12.20      Teikoku                                                                                                                                                 267

12.20.1                  Lidoderm® 1                                                                                                                        267

12.20.2                  IontoPatch®                                                                                                                        268

12.21      3M                                                                                                                                                          268

12.21.1                  3M Fentanyl Transdermal Delivery System                                                                  268

12.21.2                  3M Rivastigmine Transdermal Delivery System                                                          268

12.21.3                  Microneedles                                                                                                                        269

12.22      UCB                                                                                                                                                       269

12.22.1                  Neupro®                                                                                                                               269

12.23      ParPharm                                                                                                                                              269

12.23.1                  Fentanyl Transdermal System                                                                                          269

 

13.0        In-Depth SWOT Analysis of the Transdermal Drug Delivery Market                              270

13.1        Drivers of the Market                                                                                                                         270

13.1.1     Will Patent Expirations and Introduction of Generics Drive the Short Term Transdermal

Market?                                                                                                                                                                 270

13.1.2     Increased Patient Compliance Rates                                                                                               270

13.1.3     Increased Incidence of Chronic Conditions & Application of Patch Technology

to These Areas                                                                                                                                                     271

13.1.3.1                 Cancer                                                                                                                                   271

13.1.3.2                 Cardiovascular Disease                                                                                                      273

13.1.3.3                 Diabetes                                                                                                                                273

13.1.3.4                 Men’s Health                                                                                                                       273

13.1.3.5                 Neurological Disease                                                                                                          273

13.1.4     Increased Geriatric and Pediatric Drug Administration Requirements                                     274

13.2        Restraints and Weaknesses of the Transdermal Drug Delivery Market                                   274

13.2.1     Technical Restraints                                                                                                                           274

13.2.2     Drug Adverse Reactions                                                                                                                    275

13.2.3     Drug Failures                                                                                                                                       275

13.3        Opportunities Within the Market Place                                                                                           275

13.3.1     High Number of Pharmaco & Drug Delivery Company Collaboration                                   276

13.3.4     Targeted Transdermal Drug Delivery                                                                                              277

13.4        Challenges and Barriers to Market Entry                                                                                        277

 

Appendix 1: Further Reading & Bibliography                                                                                        279 

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